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KMID : 0368819960350020433
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Journal of the Korean Neuropsychiatr Association
1996 Volume.35 No. 2 p.433 ~ p.441
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The Relation of Clinical Improvement and Serum Prolactin Levels in the Haloperidol Tratment of Acute Schizophreniform Disorder Patients
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Abstract
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Objects:
@EN The authors investigated to evaluate the clinical utillity of serum prolactin(PRL) level as a therapeutic index of haloperidol treatment for acute psychotic patients.
@ES Methods:
@EN 22 patients(10 males, 12 females) first-onset schizophreniform disorder were studied. Among them 10 male patients; baseline PRL levels were compared to those of 11 agematched male volunteers and 11 patients who were treated with oral
haloperidol(4
males, 7 females) were studied by measuring baseline and 4the week levels of serum PRL and haloperidol and administering Positive and Negative Syndrome Scale(PANSS) concurrently.
@ES Results:
@EN 1) The serum PRL level of 10 male patients showed no statistical difference from 11 healthy males. Only the patients' pre-treatment PANSS negative subscale score had significant correlation with the baseline serum PRL level.
2) Percentage of PANSS score change didn't show significant correlation with the baseline and 4th-week serum PRL level nor with amount and percentage of serum PRL level change.
3) The total PANSS score decreased significantly after 4 week treatment with haloperidol as well as positive symptoms subscale and general psychopathology(all, p<0.05), and 4th-week serum PRL level significantly increased(p<0.01) compared with
the
baseline.
4) The 4th-week plasma haloperidol level didn't show correlation with serum PRL level nor with amount and percentage of serum PRL level change.
@ES Conclusions:
@EN The findings suggest that serum PRL level has limitation for use as therapeutic index of haloperidol treatment for acute psychotic patients.
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KEYWORD
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